L-Arginine and Pycnogenol and Citraline are the natural patented formula in Edox. which is shown to clinically improve Erectile Dysfunction.

EDOX has been proven effective in numerous clinical trials published in Medical Journals for Erectile Dysfunction
International Journal of Impotence Research Mar.Apr;20(2)173-80,2008
Improvement of Erectile Function with Prelox: A Randomized, Double-Blind, Placebo controlled crossover Trial
Stanislavov R. et al.

        *EDOX is co-marketed as Prelox in the United States.

This study looked at 50 men (30-50yrs) with ED. Each group was treated for one month. One group receiving placebo and the other received the combination of L-Arginine and 80mg. of Pycnogenol. The second month the groups were crossed over to switch which group received the placebo and which group received the L-Arginine and Pycnogenol combination. The groups that had received the combination of L-Arginine and Pycnogenol achieved normal erectile function (llEF score >25). The treated group reported improved IIEF scores from 11-17 to 26-30. The placebo group did not show significant improvement in erectile function. The combination of L-Arginine and Pycnogenol took an average of 5 days to show improvements in erectile function. The study also noted that the treatment group showed an increase in Testosterone and mean number of intercourse events. No adverse events were noted by the treatment group. The study concluded that the combination of L-Arginine and Pycnogenol appeared to offer a safe and very effective treatment alternative for the treatment of Erectile Dysfunction.

Journal of Sex and Marital Therapy, 29(3)207-213,2003

Treatment of erectile Dysfunction with Pycnogenol and L-Arginine.

Stanislavov R., et al